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Efficacy of botulinum toxin type A treatment of functional impairment of degenerative hip joint

Harris Hip score - SF36
The aim of this study was to investigate the effect of botulinum toxin type A injection into the adductor muscles in reducing pain and improving joint
mobility and quality of life in patients affected by hip osteoarthritis. METHODS:
A total of 39 outpatients, mean age 68 years
(age range 41-82 years), were
evaluated using the Harris Hip Score to test hip function, a visual analogue
scale to measure pain intensity and the Short Form 36 (SF-36) questionnaire to
assess patient well-being and quality of life at baseline, 2, 4
and 12 weeks
after treatment with botulinum toxin type A. A total of 400 U of botulinum toxin
type A (Dysport) was injected into the adductor longus muscle and the adductor
magnus muscle. RESULTS:
The Harris Hip Score increased significantly after 2, 4
and 12 weeks (df 3, chi2 = 45.1; p < 0.0001). A significant decrease in pain
intensity was detected at all the follow-up visits, after 2, 4 and 12 weeks (df
3; chi2 = 27.8; p < 0.001). The SF-36 score was significantly higher 4 and 12
weeks after treatment.
At each evaluation visit a significant correlation was
detected between decreased pain and improved hip mobility. CONCLUSION: Botulinum
toxin type A induced a reduction in pain, indicating that this might be an
innovative, less invasive treatment in patients affected by severe hip
osteoarthritis, with remarkable effects on the clinical management of this disease.

Langue : ANGLAIS

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