Article

OBJECTIVE: To investigate the feasibility and effects of a physical exercise
programme on functioning and health-related quality of life in adults with
myotonic dystrophy type 1. DESIGN: A randomized controlled trial. SUBJECTS:
Thirty-five adults with myotonic dystrophy type 1.
METHODS: After stratification
for level of functioning, study participants were assigned by lot to either a
training group or a control group. Training-group participants attended a
60-minute comprehensive group-training programme, Friskis&Svettis(R) Open Doors,
twice a week for 14 weeks. The six-minute walk test was the primary outcome
measure and the timed-stands test, the timed up-and-go test, the Epworth
sleepiness scale and the Short Form-36 health survey were secondary outcome
measures. RESULTS: Intention-to-treat analyses revealed no significant
differences in any outcome measures, except for an increased between-group
difference after intervention in the Short Form-36 mental health subscale and a
decrease in the vitality subscale for the control group. The programme was well
tolerated and many training-group participants perceived subjective changes for
the better. No negative effects were reported. CONCLUSION: The Friskis&Svettis(R)
Open Doors programme was feasible for adults with myotonic dystrophy type 1 who
had been screened for cardiac involvement, had distal or mild-to-moderate
proximal muscle impairment, and no severe cognitive impairments. No beneficial or
detrimental effects were evident.

Langue : ANGLAIS