Article

The aim of the study was to assess cognitive outcome in children with
periventricular haemorrhagic infarction (PVHI) or perinatal arterial ischaemic
stroke (PAIS) and relate these findings to early developmental outcome and
neonatal magnetic resonance imaging findings. METHOD: A neuropsychological
assessment was performed in 50 children (26 males, 24 females) with unilateral
PVHI (n=21) or PAIS (n=29) at a median age of 11 years 9 months (range 6-20y).
This included tests for intelligence, verbal memory, visual-motor integration,
word comprehension, attention, reaction times, and executive function. The
Griffiths Mental Development Scale was used for early developmental assessment at
24 months (range 18-32mo). RESULTS: In children with PVHI, both the early
Griffiths scores (mean 87; 95% CI 83-92) and the Full-scale IQ (FSIQ) scores at
school age (mean 86; 95% CI 78-94) were below the test mean of 100. In the PAIS
group, early Griffiths scores were within the normal range (mean 98; 95% CI
93-104), but at school age FSIQ scores were below average (mean 87; 95% CI
80-94). In children with PVHI, FSIQ scores correlated with the level of maternal
education and were lower after ventricular dilatation, whereas both involvement
of the basal ganglia and thalami and development of postneonatal epilepsy were
associated with lower cognitive outcome in children who had experienced PAIS.
INTERPRETATION: Cognitive outcome after PVHI or PAIS is below average, but still
within 1SD for most children. Prediction of cognitive outcome remains
challenging, but some early predictors can be recognized.
CI - (c) 2013 Mac Keith Press.

Langue : ANGLAIS