Article

Nerve conduction studies providing insight into demyelinating process are
essential for the diagnostic of chronic inflammatory demyelinating
polyradiculoneuropathy.
For the diagnostic, several sets of electrophysiologic
criteria have been established. To assess the response to treatment, nerve
conduction studies are often used in trials and in clinical practice.
Nevertheless, the useful of these classical electrophysiologic techniques is
debated because of their lack of sensibility and specificity. In the last 20
years, several works have showed that dysfunction of channels and pump of the
axonal membrane at the site and around the site of the conduction block can
precipitate conduction failure and produce weakness.
These important features
explaining clinical status are not correctly assessed by conventional nerve
conduction studies. New nerve conduction examinations in dynamic conditions can
explore these hyperexcitability modifications.
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Langue : FRANCAIS