Article

OBJECTIVE: To explore: (i) cardiovascular disease risk factors and the 10-year
clustered risk of a fatal cardiovascular event in adults with spastic bilateral
cerebral palsy; and (ii) relationships between the 10-year risk and body fat,
aerobic fitness and physical activity. DESIGN: Cross-sectional study. SUBJECTS:
Forty-three adults with spastic bilateral cerebral palsy without severe cognitive
impairment (mean age 36.6 years (standard deviation 6); 27 men). METHODS:
Biological and lifestyle-related risk factors and the 10-year risk according to
the Systematic Coronary Risk Evaluation (SCORE) were assessed. Relationships were
studied using multivariable linear regression analysis. RESULTS: The following
single risk factors were present: hypertension (n = 12), elevated total
cholesterol (n = 3), low high-density lipoprotein cholesterol (n = 5; all men),
high-risk waist circumference (n = 11), obesity (body mass index; n = 5; all
men), reduced aerobic fitness (on average 80% of reference values), reduced level
of everyday physical activity (on average 78% of reference values) and smoking
(n=9). All participants had a 10-year risk <1%. Corrected for gender,
participants with higher waist circumference (beta = 0.28; p = 0.06) or body mass
index (beta=0.25; p = 0.08) tended to have a higher 10-year risk. CONCLUSION: In
this relatively young adult sample of people with spastic bilateral cerebral
palsy several single cardiovascular disease risk factors were present. The
10-year fatal cardiovascular disease risk was low, and higher body fat tended to
be related to higher 10-year risk.

Langue : ANGLAIS