Article

Resting state functional connectivity magnetic resonance imaging studies in rat
brain show brain reorganization caused by nerve injury and repair. In this study,
distinguishable differences were found in healthy, nerve transection without
repair (R-) and nerve transection with repair (R+) groups in the subacute stage
(2 weeks after initial injury). Only forepaw on the healthy side was used to
determine seed voxel regions in this study. Disturbance of neuronal network in
the primary sensory region of cortex occurs within two hours after initial
injury, and the network pattern was restored in R+ group in subacute stage, while
the disturbed pattern remained in R- group. These are the central findings of the
study. This technique provides a novel way of detecting and monitoring the
effectiveness of peripheral nerve injury treatment in the early stage and
potentially offers a tool for clinicians to avoid poor clinical outcomes.
CI - (c) The Author(s) 2014.

Langue : ANGLAIS