Article

This perspective article proposes a conceptual model for the pain experience for
individuals diagnosed with knee osteoarthritis (OA). Pain in knee OA is likely a
heterogeneous, multifactorial phenomenon that involves not only the OA disease
process but also elements specific to patient psychology and pain
neurophysiology. The relevant contributions to the pain experience for any
individual patient remain difficult, if not impossible, to definitively
determine, and the rationale for many clinical treatment decisions arises
primarily from a mechanistic understanding of OA pathophysiology. The
Osteoarthritis Research Society International (OARSI) recently identified
"phenotyping" of OA pain as a research priority to "better target pain therapies
to individual patients." This perspective article proposes that contributions
from 3 domains--knee pathology, psychological distress, and pain
neurophysiology--should be considered equally important in future efforts to
understand pain phenotypes in knee OA. Ultimately, characterization of pain
phenotypes may aid in the understanding of the pain experience and the
development of interventions specific to pain for individual patients.

Langue : ANGLAIS