Article

AIM: To determine the current prevalence and control of major cardiovascular risk
factors in stable CAD outpatients worldwide. METHODS: We analysed variations in
cardiovascular risk factors in stable CAD outpatients from CLARIFY, a 5-year
observational longitudinal cohort study, in seven geographical zones
(Western/Central Europe; Canada/South Africa/Australia/UK; Eastern Europe;
Central/South America; Middle East; East Asia; and India). RESULTS: Patient
presentation (N=32,954, mean age 64.2 years, 78% male) varied between zones, as
did prevalence of risk factors (all p < 0.0001). Obesity ranged from 20% (East
Asia) to 42% (Middle East), raised blood pressure from 28% (Central/South America
and East Asia) to 48% (Eastern Europe), raised LDL cholesterol from 24%
(Canada/South Africa/Australia/UK) to 65% (Eastern Europe), elevated heart rate
(>/=70 bpm) from 38% (Western/Central Europe) to 78% (India), diabetes from 17%
(Eastern Europe) to 60% (Middle East), and smoking from 6% (Central/South
America) to 19% (Eastern Europe). Aspirin and lipid-lowering drugs were widely
used everywhere (>/=84% and >/=88%, respectively). Rates of risk factor control
varied geographically (all p < 0.0001). Rate of controlled blood pressure in
hypertension varied from 47% (Eastern Europe) to 66% (Central/South America),
glucose control in diabetes from 23% (India) to 51% (Western/Central Europe and
East Asia), controlled LDL cholesterol and dyslipidaemia from 32% (Eastern
Europe) to 75% (Canada/South Africa/Australia/UK), heart rate <70 bpm from 22%
(India) to 62% (Western/Central Europe), and heart rate </=60 bpm in angina
patients from 2% (India) to 29% (Canada/South Africa/Australia/UK and
Central/South America). CONCLUSION: Prevalence and control of major
cardiovascular risk factors in stable CAD vary markedly worldwide. Many stable
CAD outpatients are being treated suboptimally.
CI - (c) The European Society of Cardiology 2014.

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