Article

Patients with cerebral palsy present with a variety of adaptations to muscle
structure and function. These pathophysiologic symptoms include functional
deficits such as decreased force production and range of motion, in addition to
changes in muscle structure such as decreased muscle belly size, increased
sarcomere length, and altered extracellular matrix structure and composition. On
a cellular level, patients with cerebral palsy have fewer muscle stem cells,
termed satellite cells, and altered gene expression. Understanding the nature of
these changes may present opportunities for the development of new muscle
treatment therapies.
CI - Published by Elsevier Inc.

Langue : ANGLAIS