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Association between physical fitness and cognitive function in multiple
sclerosis : does disability status matter ?

Cognitive impairment is a highly prevalent, poorly managed, and
disabling consequence of multiple sclerosis (MS). Exercise training that improves
physical fitness represents a promising approach for managing cognitive
impairment in persons with MS. There is limited evidence that physical fitness is
associated with multiple domains of cognitive dysfunction across levels of MS
disability. OBJECTIVE: This cross-sectional study examined the associations among
aerobic capacity, lower limb muscle strength, and cognitive functions in persons
with mild, moderate, and severe MS disability. METHODS: The sample included 62
persons with mild (n = 20), moderate (n = 21), and severe (n = 21) MS disability.
The participants underwent neuropsychological assessments of cognitive processing
speed (CPS; Symbol Digit Modalities Test [SDMT]), verbal memory (California
Verbal Learning Test-2 [CVLT-2]), and visual memory (Brief Visuospatial Memory
Test-Revised [BVMT-R]). All participants further underwent testing for measuring
aerobic capacity (ie, peak oxygen consumption) and muscular strength (ie, peak
torque of knee flexors and extensors). RESULTS: Aerobic capacity and muscular
strength outcomes were associated with SDMT (r = .35-.41), but not CVLT-2 or
BVMT-R (r < .19) scores in the overall sample. Aerobic capacity (r = .42) and
knee flexor peak torque (r = .39) were associated with SDMT scores in persons
with mild disability, but not in those with moderate (r < .06) and severe (r <
.14) disability. CONCLUSIONS: These results support examining aerobic and
resistance exercise training programs for improving CPS, particularly among
persons with mild MS disability.
CI - (c) The Author(s) 2014.

Langue : ANGLAIS

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