Article

Obesity and overweight are strongly associated with cardiovascular
morbidity and mortality. However, there are limited data on the association
between excess weight and the risk of ectopic ventricular activity. DESIGN AND METHODS:
We investigated the association between body mass index (BMI) and the
risk for ectopic ventricular activity (defined as multiple ventricular premature
beats (>/=3), ventricular bigeminy, nonsustained ventricular tachycardia or
sustained ventricular tachycardia) during exercise stress testing among 22,516
apparently healthy men and women who attended periodic health screening
examinations between the years 2000 and 2014. All subjects had completed maximal
exercise stress testing annually according to the Bruce protocol. Subjects were
divided at baseline into three groups: normal weight (BMI >/= 18.5 kg/m(2)
and<25; N = 9,994), overweight (BMI >/= 25 and < 30; N = 9,613) and obese (BMI
>/= 30; N = 2,906). RESULTS: The mean age of study subjects was 47 +/- 10 years
and 72% were men. Kaplan-Meier survival analysis showed that the cumulative
probability for the development of exercise-induced ectopic ventricular activity
arrhythmias was highest among obese subjects, intermediate among overweight
subjects and lowest among subjects with normal weight (3.4%, 2.7% and 2.2%
respectively; p < 0.001). Multivariate binary logistic regression with repeated
measures of 92,619 ESTs, showed that obese subjects were 33% more likely to have
ectopic ventricular arrhythmias during exercise compared with subjects with
normal weight (p = 0.005), and that each 1 kg/m(2) increase in BMI was associated
with a significant 4% (p = 0.002) increased adjusted risk for exercise-induced
ventricular arrhythmias. CONCLUSION: Obesity is independently associated with
increased likelihood of ectopic ventricular arrhythmia during exercise.
CI - (c) The European Society of Cardiology 2015.

Langue : ANGLAIS