Article

OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic
fitness, muscle strength, and core stability also had an impact on fatigue, pain,
activity, and participation in adults with Pompe disease, an inherited
neuromuscular disorder. DESIGN: Open-label trial. Change was assessed by the
chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices.
PARTICIPANTS: Mildly affected adult patients with Pompe disease who were not
dependent on ventilators and/or walking devices and were receiving enzyme
replacement therapy. INTERVENTION: Patients participated in a 12-week exercise
program, which included 36 sessions of standardized aerobic, resistance, and core
stability exercises. MAIN OUTCOME MEASURES: Before and after the training program
we evaluated fatigue (Fatigue Severity Scale), pain (yes/no), motor function
(Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale),
amount of physical activity (activity monitor), and health status (Medical
Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 patients
enrolled, 23 completed the program. At the end of the program, levels of fatigue
(median, 5.33 to 4.78, P=.01) and pain (56.5% to 21.7%, P=.04) improved. The
quality of motor function and the amount of physical activity patients engaged in
did not change. Changes in pain and fatigue were not related to improvements in
aerobic fitness or muscle strength. CONCLUSIONS:
This study in mildly affected
adult patients with Pompe disease suggests that a combined training program
aiming to increase aerobic fitness, muscle strength, and core stability also
leads to improvements in fatigue and pain.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS