Article

Optogenetics is the combination of optical tools to monitor (i.e. "reporters") or
interfere (i.e. "actuators") with neural activity, and genetic techniques to
restrain the expression of these reporters and actuators in the neuronal
populations of interest. Such combination of optical and genetic tools, together
with the emergence of new animal models such as the zebrafish larva, has proven
extremely valuable is dissecting neural circuits. Optogenetics provide a new
framework to address issues that are fundamentally dynamic processes, such as
sensorimotor integration in the vertebrate spinal cord. By shifting from
spatially targeted electrical stimulation to genetically targeted optical
stimulation, optogenetic also opens new avenues for innovative
neurorehabilitative strategies, in particular after spinal cord injury.
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Langue : ANGLAIS