Article

OBJECTIVE: To investigate the effect of ramelteon on sleep and daytime
functioning among individuals with traumatic brain injury (TBI). DESIGN: A double-blind, placebo-controlled study with a crossover design. SETTING: A
research facility attached to an acute rehabilitation hospital. PARTICIPANTS:
Individuals with TBI (N=13) complaining of sleep difficulties with a Pittsburgh
Sleep Quality Index score >5. INTERVENTIONS: A nightly dosage of ramelteon (8 mg)
was given over a period of 3 weeks. MAIN OUTCOME MEASURES: An actigraph and a
daily sleep log were used to measure sleep/wake patterns. Daytime functioning was
measured after 3 weeks of treatment using a computer-administrated
neuropsychological test battery in conjunction with subjective questionnaires
measuring mood, daytime sleepiness, and fatigue. RESULTS: A significant increase
in objectively measured total sleep time and a small increase in sleep latency
were observed after 3 weeks of treatment compared with placebo. Treatment also
showed a significant increase in standardized neuropsychological test scores,
with a particular improvement on an index of executive functioning. CONCLUSIONS:
Preliminary evidence for the effectiveness of 8 mg of ramelteon taken nightly
over a 3-week period was found in the treatment of sleep difficulties among
individuals with TBI. Improvements in total sleep time and some aspects of
cognitive functioning are discussed.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS