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High Intensity Aerobic and Resistance Exercise Can Improve Glucose Tolerance in Persons With Multiple Sclerosis

WENS I; DALGAS U; VANDENABEELE F; VERBOVEN K; HANSEN D; DECKX N; COOLS N; EIJNDE BO
AM J PHYS MED REHABIL , 2017, vol. 96, n° 3, p. 161-166
Doc n°: 182546
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1097/PHM.0000000000000563
Descripteurs : AE3 - SEP, ND - EXERCICE PHYSIQUE

The prevalence of impaired glucose tolerance (IGT) is higher in persons with multiple sclerosis (MS) compared to healthy controls, indicating
metabolic deficits that may increase comorbidity. In other populations, IGT can,
at least partly, be reversed by intense physical exercise, but this is never
investigated before in MS.
AIM: To investigate the effect of high intensity
aerobic and resistance training on glucose tolerance and skeletal muscle GLUT4
content in MS. METHODS: Thirty-four persons with MS (aged 45 +/- 3 years, EDSS
2.5 +/- 1.07) were randomized into three groups, including a (1) sedentary
control group (SED, n = 11), (2) 12-week high intensity interval plus resistance
training group (HITR, n = 12), or (3) 12-week high intensity continuous aerobic
training plus resistance training group (HCTR, n = 11). Before and after 12
weeks, glucose tolerance and skeletal muscle GLUT4 content were determined by an
oral glucose tolerance test and analysis of a m.vastus lateralis biopsy,
respectively. RESULTS: There were no significant changes for subjects of SED.
From pre- to post-intervention, total area under the glucose curve (tAUC)
decreased significantly in both HITR (-6.9 +/- 6.2%) and HCTR (-11.0 +/- 7.7%) (P
< 0.05). Insulin tAUC decreased (-12.3 +/- 14.7%) within HCTR and muscle GLUT4
content increased (+6.6 +/- 4.5%) in HITR. CONCLUSION: Twelve weeks of high
intensity aerobic exercise in combination with resistance training improved
glucose tolerance in persons with MS.

Langue : ANGLAIS

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