RééDOC
75 Boulevard Lobau
54042 NANCY cedex

Christelle Grandidier Documentaliste
03 83 52 67 64


F Nous contacter

0

Article

--";3! O
     

-A +A

Abnormal Spontaneous Brain Activity in Acute Low-Back Pain Revealed by Resting-State Functional MRI

ZHANG SS; WU W; YANG JM; WANG CH
AM J PHYS MED REHABIL , 2017, vol. 96, n° 4, p. 253-259
Doc n°: 182552
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1097/PHM.0000000000000597
Descripteurs : CE51 - LOMBALGIE, AF12 - PATHOLOGIQUE

Neuroimaging studies have revealed that low-back pain (LBP) alters
spatiotemporal dynamics of the blood oxygen level-dependent signal in response to
persistent noxious stimulus.
This study aimed to investigate changes in
spontaneous neural activity of various brain regions in acute LBP using
resting-state functional magnetic resonance imaging and amplitude of
low-frequency fluctuation (ALFF). DESIGN: Twelve healthy subjects underwent two
separate resting-state functional magnetic resonance imaging scans at health
status as baseline and after intramuscular injection of hypertonic saline (0.5
mL, 5%) into the back muscles to induce acute LBP.
RESULTS: Compared with
baseline, acute LBP showed decreased ALFF in the right posterior cingulate
cortex/precuneus and left primary somatosensory cortex (S1) but increased ALFF in
the right medial prefrontal cortex, right middle temporal gyrus, bilateral
inferior temporal gyrus, bilateral insula, right anterior cingulate cortex, and
left cerebellum. In addition, significant negative correlations were observed
between visual analog scale scores and ALFF of the bilateral medial prefrontal
cortex, left inferior frontal gyrus, left S1, right anterior cingulate cortex,
and left middle temporal gyrus. CONCLUSIONS: These findings suggest that
abnormally spontaneous neural activity involving some brain regions are
responsible for sensory, affective, and cognitive functions, which may be
implicated in the underlying pathophysiology of acute LBP.

Langue : ANGLAIS

Mes paniers

4

Gerer mes paniers

0