Article

OBJECTIVE: To determine whether baseline levels of pain, fatigue, sleep
disturbance, and physical activity measured at the initial assessment predicted
the development of or improvement of depression 3.5 years later, while
controlling for sex, age, and disease severity.
DESIGN: Observational,
longitudinal survey study. SETTING: A community-based population sample.
PARTICIPANTS: Adults with multiple sclerosis (MS) (N=489). INTERVENTIONS: Not
applicable. MAIN OUTCOME MEASURE: Primary outcome was classification of
depression group measured using a Patient Health Questionnaire-9 cutoff score
>/=10, indicating probable major depression. RESULTS: Fatigue severity (odds
ratio, 1.19; 95% confidence interval, 1.12-1.26; P<.0001) and sleep disturbance
(odds ratio, 1.06; 95% confidence interval, 1.02-1.10; P=.001) predicted probable
major depression 3.5 years later among those not depressed at the initial
assessment. An effect of age (odds ratio, .96; 95% confidence interval, .92-.99;
P=.008) was found among those who developed depression, indicating that younger
adults were more likely to develop depression. Pain, fatigue, sleep, and physical
activity at baseline were not significantly associated with recovery from
depression among those depressed at the initial assessment.
CONCLUSIONS: Fatigue
and sleep may contribute to the development of depression. Clinical trial
research targeting these variables to determine their influence on depression is
warranted.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS