Article

Two thirds of stroke survivors experience motor impairment resulting
in long-term disability. The anatomical substrate is often the disruption of
cortico-subcortical pathways. It has been proposed that reestablishment of
cortico-subcortical communication relates to functional recovery.
OBJECTIVE: In
this study, we applied a novel training protocol to augment ipsilesional
cortico-subcortical connectivity after stroke. Chronic stroke patients with
severe motor impairment were provided online feedback of blood-oxygenation level
dependent signal connectivity between cortical and subcortical regions critical
for motor function using real-time functional magnetic resonance imaging
neurofeedback. RESULTS: In this proof of principle study, 3 out of 4 patients
learned to voluntarily modulate cortico-subcortical connectivity as intended.
CONCLUSIONS: Our results document for the first time the feasibility and safety
for patients with chronic stroke and severe motor impairment to self-regulate and
augment ipsilesional cortico-subcortical connectivity through neurofeedback using
real-time functional magnetic resonance imaging.
CI - (c) The Author(s) 2015.

Langue : ANGLAIS