Article

AIM: To examine the association between newborn neurobehavioural assessments and
neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm
(MLPT). METHOD: Two-hundred and one infants born MLPT
(born 32-36+6 wks'
gestation) were assessed with the Hammersmith Neonatal Neurological Examination
(HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance
defined as scores lower than the 10th centile. Development was assessed at 2
years corrected age with the Bayley Scales of Infant and Toddler Development 3rd
Edition, with delay defined as scores less than 1 standard deviation (SD) below
the mean. The relationships between neurobehaviour at term and Bayley-III
cognitive, language, and motor scales at 2 years were examined using linear
regression. RESULTS: Increased odds for cognitive delay were associated with
suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI]
1.14-6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33-6.82,
p=0.008) and lethargy (OR 4.05; 95% CI 1.75-9.31, p=0.001) scores. Suboptimal
lethargy scores on the NNNS were associated with increased odds of language (OR
5.64; 95% CI 1.33-23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64-28.71,
p=0.08). INTERPRETATION: Suboptimal performance on specific aspects of newborn
neurobehavioural assessments is associated with neurodevelopmental delay at 2
years in children born MLPT.
CI - (c) 2016 Mac Keith Press.

Langue : ANGLAIS