Article

AIM: To examine the associations between Prechtl's General Movements Assessment
(GMA), conducted from birth to term-equivalent age, and neurodevelopmental
outcomes at 12 months corrected age, in infants born very preterm. METHOD: One
hundred and thirty-seven infants born before 30 weeks' gestation had serial GMA
(categorized as 'normal' or 'abnormal') before term and at term-equivalent age.
At 12 months corrected age, neurodevelopment was assessed using the Alberta
Infant Motor Scale (AIMS); Neurological, Sensory, Motor, Developmental Assessment
(NSMDA); and Touwen Infant Neurological Examination (TINE). The relationships
between GMA at four time points and 12-month neurodevelopmental assessments were
examined using regression models. RESULTS: Abnormal GMA at all time points were
associated with worse continuous scores on the AIMS, NSMDA, and TINE (p<0.05).
Abnormal GMA before term and at term-equivalent age were associated with
increased odds of mild-severe dysfunction on the NSMDA (odds ratio [OR] 4.26, 95%
confidence interval [CI] 1.55-11.71, p<0.01; and OR 4.16, 95% CI 1.55-11.17,
p<0.01 respectively) and abnormal GMA before term with increased odds of
suboptimal-abnormal motor function on the TINE (OR 2.75, 95% CI 1.10-6.85,
p=0.03). INTERPRETATION: Abnormal GMA before term and at term-equivalent age were
associated with worse neurodevelopment at 12 months corrected age in children
born very preterm. WHAT THIS PAPER ADDS: Abnormal general movements before term
predict developmental deficits at 1 year in infants born very preterm. General
Movements Assessment before term identifies at-risk infants born very preterm.
CI - (c) 2017 Mac Keith Press.

Langue : ANGLAIS