Article

Fatigue is the most common symptom in multiple sclerosis.
Evidence-based treatment options are scarce. OBJECTIVE: To study the feasibility
and potential effectiveness of mindfulness-based cognitive therapy in severely
fatigued multiple sclerosis patients. METHODS: Non-randomized pilot study with a
wai-ting list control period including 59 multiple sclerosis patients with severe
fatigue. PRIMARY OUTCOME MEASURE: fatigue severity subscale of the Checklist
Individual Strength-20. Secondary measures:
Hospital Anxiety and Depression
Scale, Life Satisfaction Questionnaire, subscale sleep of the Symptom
Checklist-90, Cognitive Failure Questionnaire, Fatigue Catastrophizing Scale,
Coping Inventory of Stressful Situations, and Five Facet Mindfulness
Questionnaire-Short Form. Measurements were taken before treatment (double
baseline), after treatment, and at follow-up (3 months). RESULTS: Adherence rate
was 71%. Eight out of 10 participants who completed the intervention were
satisfied with the intervention. Significant time effects were found for 7 out of
11 outcome measures (p = 0.006 to < 0.001). The effect size was moderate for all
outcome measures that were significant post-treatment and/or at follow-up ((2) =
0.10-0.17). Improvements were maintained at follow-up.
Of the completers, 46%
showed a clinically relevant change regarding fatigue. CONCLUSION:
Mindfulness-based cognitive therapy is feasible in severely fatigued multiple
sclerosis patients and has positive results in the reduction of severe fatigue
and several psychological factors.

Langue : ANGLAIS