Article

Event-related potentials have repeatedly revealed
electrophysiological markers of cognitive dysfunction associated with Mild
Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide
cognitive rehabilitative interventions. We previously found patients with
symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a
NoGo-P3 subcomponent in the acute phase of the injury.
The goal of this
longitudinal study was to investigate whether this early NoGo-P3 subcomponent
differs over time in symptomatic MTBI patients and healthy controls. METHODS: We
included adults with a diagnosis of MTBI and individually matched healthy
controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were
assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was
collected by using a cued Go/NoGo task and the relevant subcomponent was
extracted by independent component analysis. RESULTS: Among 53 adults with a
diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35
matched healthy controls (18 females each group; mean age 34.06+/-13.15 and
34.26+/-12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower
for symptomatic MTBI patients than controls (P<0.05) at 1 week post-injury.
Furthermore, mixed ANOVA revealed a significant time by group interaction
(P<0.05), so the effect of time differed for symptomatic MTBI patients and
healthy controls. The amplitudes for MTBI patients normalized from 1 week to 3
months post-injury and were comparable to those of controls from 3 months to 1
year post-injury. However, amplitudes for 3 MTBI patients with particularly
severe complaints 1 year post-injury did not normalize and were lower than those
for the remaining MTBI sample (P<0.05). CONCLUSIONS: Selected event-related
potentials can be used as a sensitive and objective tool to illustrate the
cognitive consequences of and recovery after MTBI.
CI - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS