Article

This study aimed to examine differences in spatiotemporal gait
parameters between older adults with amnestic mild cognitive impairment and
normal cognition and to examine limbic and basal ganglia neural correlates of
gait and executive function in older adults without dementia. DESIGN: This was a
cross-sectional study of 46 community-dwelling older adults, ages 70-95 yrs, with
amnestic mild cognitive impairment (n = 23) and normal cognition (n = 23).
Structural magnetic resonance imaging was used to attain volumetric measures of
limbic and basal ganglia structures. Quantitative motion analysis was used to
measure spatiotemporal parameters of gait. The Trail Making Test was used to
assess executive function. RESULTS: During fast-paced walking, older adults with
amnestic mild cognitive impairment demonstrated significantly slower gait speed
and shorter stride length compared with older adults with normal cognition.
Stride length was positively correlated with hippocampal, anterior cingulate, and
nucleus accumbens volumes (P < 0.05). Executive function was positively
correlated with hippocampal, anterior cingulate, and posterior cingulate volumes
(P < 0.05). CONCLUSIONS: Compared with older adults with normal cognition, those
with amnestic mild cognitive impairment demonstrated slower gait speed and
shorter stride length, during fast-paced walking, and lower executive function.
Hippocampal and anterior cingulate volumes demonstrated moderate positive
correlation with both gait and executive function, after adjusting for age. TO
CLAIM CME CREDITS: Complete the self-assessment activity and evaluation online at
http://www.physiatry.org/JournalCME CME OBJECTIVES: Upon completion of this
article, the reader should be able to: (1) discuss gait performance and cognitive
function in older adults with amnestic mild cognitive impairment versus normal
cognition, (2) discuss neurocorrelates of gait and executive function in older
adults without dementia, and (3) recognize the importance of assessing gait speed
and cognitive function in the clinical management of older adults at risk for
dementia. LEVEL: Advanced ACCREDITATION: The Association of Academic Physiatrists
is accredited by the Accreditation Council for Continuing Medical Education to
provide continuing medical education for physicians.The Association of Academic
Physiatrists designates this Journal-based CME activity for a maximum of 0.5 AMA
PRA Category 1 Credit(s). Physicians should only claim credit commensurate with
the extent of their participation in the activity.

Langue : ANGLAIS