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Cognitive outcomes in children and adolescents born very preterm

AIM: To estimate the association between very preterm birth (<32wks' gestation)
and intelligence, executive functioning, and processing speed throughout
childhood and adolescence, and to examine the effects of gestational age,
birthweight, and age at assessment. METHOD: Studies were included if children
were born at earlier than 32 weeks' gestation, aged 4 to 17 years, had an
age-matched term control group, and if the studies used standardized measures,
were published in an English-language peer-reviewed journal, and placed no
restrictions on participants based on task performance. RESULTS: We evaluated
6163 children born very preterm and 5471 term-born controls from 60 studies.
Children born very preterm scored 0.82 SDs (95% confidence interval [CI]
0.74-0.90; p<0.001) lower on intelligence tests, 0.51 SDs (95% CI 0.44-0.58;
p<0.001) lower on measures of executive functioning, and 0.49 SDs (95% CI
0.39-0.60; p<0.001) lower on measures of processing speed than term-born
controls. Gestational age and birthweight were associated with study effect size
in intelligence and executive functioning of younger children only. Age at
assessment was not associated with study effect size. INTERPRETATION: Children
born very preterm have medium to large deficits in these cognitive domains. WHAT
This meta-analysis is centred on very preterm birth and three
cognitive domains. The three critical cognitive domains are intelligence,
executive functioning, and processing speed.
CI - (c) 2018 Mac Keith Press.

Langue : ANGLAIS

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