Article

Previous studies have suggested that shift work is associated with a
higher risk of cardiovascular disease. However, the quantitative dose-response
relationship between duration of shift work and cardiovascular disease risk is
still unknown. We aimed to evaluate the dose-response association between
duration of shift work and risk of cardiovascular disease morbidity and
mortality. Design A systematic review and meta-analysis. Methods PubMed and
Embase were searched from inception to 1 December 2017. Prospective cohort
studies that reported the associations between duration of shift work and
cardiovascular disease risk with at least three categories were included. Data
were pooled by using fixed or random effect models. The continuous dose-response
associations were assessed by using fixed effect restricted cubic splines with
four knots. Results Five prospective cohort studies with 10 reports were
included. No evidence of a curvilinear association was observed between duration
of shift work and risk of cardiovascular disease, similar findings were observed
in cardiovascular disease morbidity and mortality. The summary relative risk (RR)
of an increase of 5 years of shift work was 1.05 (1.04-1.07) with moderate
heterogeneity ( P = 0.142, I(2 )= 33.2%) for cardiovascular disease, 1.06
(1.04-1.08) with low heterogeneity ( P = 0.279, I(2 )= 21.7%) for cardiovascular
disease morbidity, and 1.04 (1.02-1.06) with moderate heterogeneity ( P = 0.135,
I(2 )= 38.5%) for cardiovascular disease mortality, respectively. Conclusions
Shift work could probably increase the risk of cardiovascular disease and
cardiovascular disease mortality in a dose-response way.
These findings could
have implications for guideline recommendations regarding the risk related to shift schedules.

Langue : ANGLAIS