Article

OBJECTIVE: To examine the role of the protein S100B as a biomarker for traumatic
brain injury (TBI) in the presence of acute alcohol intoxication. PARTICIPANTS: A
total of 159 patients who presented to a large urban level 1 trauma center in
Vancouver, British Columbia, Canada, were included. Patients were classified into
4 clinical groups-medical controls (MC), trauma controls (TC), uncomplicated mild
TBI (MTBI), and definite TBI (DTBI)-and 2 day-of-injury alcohol intoxication
groups (ie, sober and intoxicated). PROCEDURE: Blood samples were collected
within 8 hours of injury.
MAIN OUTCOME MEASURE: Protein S100B concentration
(mug/L; Sangtec 100 Elisa, DiaSorin, Stillwater, Minnesota). RESULTS: Higher
S100B levels were found in patients who sustained a TBI than in those in the MC
and TC groups (DTBI & MTBI >TC & MC). There was a positive linear relation
between S100B levels and brain injury severity (DTBI > MTBI). Alcohol consumption
at the time of injury did not generally affect S100B levels. The S100B levels had
medium diagnostic accuracy for the majority of patients, with the exception of
the DTBI-sober group in which S100B levels had very high diagnostic accuracy.
CONCLUSION: Patients with uncomplicated MTBIs and DTBIs had much higher levels of
S100B than MC and TC participants. This biomarker had medium diagnostic accuracy
for detecting DTBI in the presence of alcohol intoxication and very high accuracy
in sober patients.

Langue : ANGLAIS