Article

Chronic ischaemic cardiovascular disease (CICD) remains a leading cause of
morbidity and mortality worldwide. The CICD Pilot Registry enrolled 2420 patients
across 10 European Society of Cardiology countries prospectively to describe
characteristics, management strategies and clinical outcomes in this setting. We
report here the six-month outcomes. Methods and results From the overall
population, 2203 patients were analysed at six months.
Fifty-eight patients
(2.6%) died after inclusion; 522 patients (23.7%) experienced all-cause
hospitalisation or death. The rate of prescription of angiotensin-converting
enzyme inhibitors, beta-blockers and aspirin was mildly decreased at six months
(all P < 0.02). Patients who experienced all-cause hospitalisation or death were
older, more often had a history of non-ST-segment elevation myocardial
infarction, of chronic kidney disease, peripheral revascularisation and/or
chronic obstructive pulmonary disease than those without events. Independent
predictors of all-cause mortality/hospitalisation were age (hazard ratio (HR)
1.17, 95% confidence interval (CI) 1.07-1.27) per 10 years, and a history of
previous peripheral revascularisation (HR 1.45, 95% CI 1.03-2.03), chronic kidney
disease (HR 1.31, 95% CI 1.0-1.68) or chronic obstructive pulmonary disease (HR
1.42, 95% CI 1.06-1.91, all P < 0.05). We observed a higher rate of events in
eastern, western and northern countries compared to southern countries and in
cohort 1. Conclusion In this contemporary European registry of CICD patients, the
rate of severe clinical outcomes at six months was high and was influenced by
age, heart rate and comorbidities. The medical management of this condition
remains suboptimal, emphasising the need for larger registries with long-term
follow-up. Ad-hoc programmes aimed at implementing guidelines adherence and
follow-up procedures are necessary, in order to improve quality of care and
patient outcomes.

Langue : ANGLAIS