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A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis

OBJECTIVE: To explore the feasibility and effects of a computer-assisted
cognitive rehabilitation intervention - Memory, Attention, and Problem Solving
Skills for Persons with Multiple Sclerosis (MAPSS-MS) - for persons with multiple
sclerosis on cognitive performance, memory strategy use, self-efficacy for
control of symptoms and neuropsychological competence in activities of daily
living (ADL). DESIGN: A randomized controlled single-blinded trial with treatment
and wait list control groups. Setting: Southwestern United States. Subjects:
Convenience sample of 61 persons (34 treatment, 27 wait list control) with
multiple sclerosis (mean age 47.9 years, SD 8.8). INTERVENTION: The eight-week
MAPSS-MS intervention program included two components: (a) eight weekly group
sessions focused on building efficacy for use of cognitive compensatory
strategies and (b) a computer-assisted cognitive rehabilitation program with
home-based training. OUTCOME MEASURES: A neuropsychological battery of
performance tests comprising the Minimal Assessment of Cognitive Function in
Multiple Sclerosis (MACFIMS) and self-report instruments (use of memory
strategies, self-efficacy for control of multiple sclerosis and
neuropsychological competence in ADL) were completed at baseline, two months
(after classes), and at five months. RESULTS: Both groups improved significantly
(P < 0.05) over time on most measures in the MACFIMS battery as well as the
measures of strategy use and neuropsychological competence in ADL. There was a
significant group-by-time interaction for scores on the measures of verbal memory
and the use of compensatory strategies. CONCLUSIONS: The MAPSS-MS intervention
was feasible and well-accepted by participants. Given the large relative increase
in use of compensatory strategies by the intervention group, it holds promise for
enhancing cognitive function in persons with multiple sclerosis.

Langue : ANGLAIS

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