Article

AIM: To assess the time trends of neonatal survival and infant neurodevelopmental
outcome in very-low-birthweight children at 24 months corrected age over a
20-year period. METHOD:
The study cohort comprised 857 infants (439 males and 418
females) weighing less than 1500g at birth or delivered before 32 weeks
gestational age in the period 1989 to 2008. Neurological examination and
cognitive assessment of the infants (Bayley Scales of Infant Development and
Griffiths Mental Developmental Scale) were performed at 24 months corrected age.
RESULTS: The prevalence of neonatal survival with normal neurodevelopmental
outcome increased from 55.3% (104/188) in 1989 to 1993, to 61.4% in 1994-1998
(116/189), 68.3% in 1999 to 2003 (138/202), and 84.5% in 2004 to 2008 (235/278)
(annual increase=1%, 95% CI 2.1-4.1; p<0.001). In logistic models, the increase
in the rate of normal neurodevelopmental outcome during the periods studied was
consistent across the categories of birthweight (1000g),
gestational age (28wks),
and clinical characteristics
(pre-eclampsia/growth restriction as opposed to spontaneous prematurity/rupture
of membranes). INTERPRETATION: The increased rate of normal neurodevelopmental
outcome at 2 years among very-low-birthweight infants is independent of obstetric
risk factors.
CI - (c) 2015 Mac Keith Press.

Langue : ANGLAIS