Article

Improvements in cancer screening, diagnosis, and treatment have resulted in an
increasing population of cancer survivors with impairments in physical function,
cancer-related symptoms, and reduced quality of life. Exercise and physical
activity have therapeutic value at multiple points along the cancer disease
continuum, spanning disease prevention, treatment, survivorship, prognostic
outcomes, and end-of-life issues. Molecular mechanisms for the influence of
exercise in persons with cancer include altering tumor initiation pathways and
affecting hormonal, inflammatory, immune, and insulin pathways. Physical activity
has been found to play a role in the prevention of certain malignancies,
including breast, colon, and other cancers. An increasing amount of evidence
indicates that physical activity may affect prognostic outcomes in certain cancer
diagnoses, especially breast cancer. Structured exercise and physical activity
interventions can be helpful in addressing specific survivorship issues,
including overall quality of life, cardiorespiratory impairment, cancer-related
fatigue, and lymphedema. Exercise also may be helpful during the palliative care
phase to alleviate symptoms and increase physical well-being. This article will
familiarize physiatrists with the current state of evidence regarding the role
and efficacy of exercise in persons with cancer.
CI - Copyright (c) 2012 American Academy of Physical Medicine and Rehabilitation.
Published by Elsevier Inc. All rights reserved.

Langue : ANGLAIS