Article

Declining ambulatory activity represents an important facet of
disablement in Parkinson disease (PD). OBJECTIVE:
The primary study aim was to
compare the 2-year trajectory of ambulatory activity decline with concurrently
evolving facets of disability in a small cohort of people with PD. The secondary
aim was to identify baseline variables associated with ambulatory activity at 1-
and 2-year follow-up assessments. This was a prospective, longitudinal
cohort study. METHODS: Seventeen people with PD (Hoehn and Yahr stages 1-3) were
recruited from 2 outpatient settings. Ambulatory activity data were collected at
baseline and at 1- and 2-year annual assessments. Motor, mood, balance, gait,
upper extremity function, quality of life, self-efficacy, and levodopa equivalent
daily dose data and data on activities of daily living also were collected.
RESULTS: Participants displayed significant 1- and 2-year declines in the amount
and intensity of ambulatory activity concurrently with increasing levodopa
equivalent daily dose. Worsening motor symptoms and slowing of gait were apparent
only after 2 years. Concurrent changes in the remaining clinical variables were
not observed. Baseline ambulatory activity and physical performance variables had
the strongest relationships with 1- and 2-year mean daily steps. LIMITATIONS: The
sample was small and homogeneous. CONCLUSIONS: Future research that combines
ambulatory activity monitoring with a broader and more balanced array of measures
would further illuminate the dynamic interactions among evolving facets of
disablement and help determine the extent to which sustained patterns of
recommended daily physical activity might slow the rate of disablement in PD.
CI - (c) 2015 American Physical Therapy Association.

Langue : ANGLAIS