Article

OBJECTIVE: To provide a clinically useful means of interpreting change for
individual patients on the Quality of Life in Neurological Disorders (Neuro-QoL)
adult short forms (SFs) by applying a classical test theory concept for
interpreting individual change. DESIGN: Secondary analysis of existing data.
SETTING: Community. PARTICIPANTS: Persons with neurologic conditions including
stroke, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, and
Parkinson disease residing in community settings. INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Neuro-QoL SFs for Applied Cognition-General Concerns,
Applied Cognition-Executive Function, Applied Cognition-Combined, Ability to
Participate in Social Roles and Activities, Satisfaction With Social Roles and
Activities, Positive Affect and Well-Being, Depression, Stigma, Upper Extremity
Function (Fine Motor, Activities of Daily Living), Lower Extremity Function
(Mobility), Anxiety, Sleep Disturbance, Fatigue, and Emotional and Behavioral
Dyscontrol. We estimated conditional minimal detectable change (cMDC) indices
from the pooled SEs adjusted for a 95% confidence interval using the average of
the SEs for any given pair of scores multiplied by the z score, or ([SEScore1 +
SEScore2]/2) * (1.96) * (SQRT(2)). RESULTS: The cMDC indices are generally
smallest in the midrange of all scales, ranging from 3.6 to 11.2 T-score points,
and higher on the outer quartiles ranging from 3.7 to 21.6 T-score points. The
lowest midrange cMDCs were for Satisfaction With Social Roles and Activities
(3.6-4.7 T-score points), and the largest were for Sleep Disturbance (9.4-11.2
T-score points). CONCLUSIONS: Change indices can help clinicians and
investigators identify differences for individual patients or subjects that are
large enough to motivate treatment change. cMDCs can reduce misclassification of
magnitudes of change that are near the margins of error across the range of the
Neuro-QoL SFs.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS