Article

Dementia with Lewy bodies (DLB) is the second cause of degenerative dementia in
autopsy studies. In clinical pratice however, the prevalence of DLB is much lower
with important intercenter variations. Among the reasons for this low sensitivity
of DLB diagnosis are (1) the imprecision and subjectivity of the diagnostic
criteria; (2) the underestimation of non-motor symptoms (REM-sleep behavior
disorder, dysautonomia, anosmia); mostly (3) the nearly constant association of
Lewy bodies with Alzheimer's disease pathology, which dominates the clinical
phenotype. With the avenue of targeted therapies against the protein agregates,
new clinical scales able to apprehend the coexistence of Lewy pathology in
Alzheimer's disease are expected.
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Langue : FRANCAIS