Article

OBJECTIVES: To assess the effects of short-term resistance training and pulsed
electromagnetic fields on bone metabolism and joint function in patients with
haemophilia with osteoporosis. DESIGN: A randomized, controlled, patient and
blood sample assessor-blinded, six-week trial, three times weekly. SETTING: Hospital outpatients with severe haemophilia A and osteoporosis. SUBJECTS:
Forty-eight patients were randomly assigned to resistance training (RT, n = 13),
combined resistance training with pulsed electromagnetic fields (RTPEMF, n = 12),
pulsed electromagnetic fields (PEMF, n = 11) and control
(n = 12) groups.
INTERVENTION: The RT group received 30-40 minutes of resistance exercises and
placebo pulsed electromagnetic fields. The RTPEMF group received the same
exercises with lower repetition and 30 minutes of pulsed electromagnetic fields.
The PEMF group was exposed to 60 minutes of pulsed electromagnetic fields (30 Hz
and 40 Gauss). MAIN MEASURES: Bone-specific alkaline phosphatase, N-terminal
telopeptide of type 1 collagen, and joint function, using the modified Colorado
Questionnaire, were measured before and after the programme. RESULTS: The
absolute change of bone-specific alkaline phosphatase was significant in the RT
and RTPEMF groups compared with the control group (25.41 +/- 14.40, 15.09 +/-
5.51, and -4.73 +/- 2.93 U/L, respectively). The absolute changes in the total
score for joint function were significant for knees, ankles,
and elbows in the RT
group (9.2 +/- 1.38, 5.1 +/- 0.5, and 3.2 +/- 0.8, respectively) and the RTPEMF
group (7.7 +/- 1.0, 3.3 +/- 0.6, and 2.5 +/- 0.7, respectively) compared to the
PEMF and control groups.
This value was significant for knee joints in the PEMF
group compared to the control group (3.4 +/- 0.5 and 0.66 +/- 0.4, respectively).
CONCLUSIONS: Resistance training is effective for improving bone formation and
joint function in severe haemophilia A patients with osteoporosis.

Langue : ANGLAIS