Article

Knowledge of which factors are determinant of quality of life (QoL)
in patients with multiple scleroris (MS) would assist clinicians in choosing the
most appropriate interventions.
The aim of this study was to determine the
contribution of sociodemographic and clinical factors in the predicting QoL in a
2-year cohort of patients with relapsing-remitting MS (RR-MS). METHODS: The study
had a multi-center, multi-regional, and longitudinal design. Main inclusion
criteria were: patient with a RR-MS subtype (McDonald criteria) and an Expanded
Disability Status Scale (EDSS) score lower than 7.0. Sociodemographic (age,
gender, education level, marital and employment status) and clinical (disability,
disease duration, relapse) data were recorded. The QoL was assessed using the
MusiQoL (disease-specific) and SF-36 (generic) questionnaires. Each patient was
investigated at baseline and 24 months post-inclusion (ClinicalTrials.gov
identifier: NCT00702065). RESULTS: Five hundred and twenty-six patients were
enrolled in the present study. The 24-month MusiQoL index score was significantly
inversely correlated with the disease duration. Baseline EDSS score impacted in
both 'physical-like' and 'psychological-like' dimensions. At least one relapse
during the follow-up period was associated with lower physical scores.
Occupational status and marital status were associated with 24-month scores of
MusiQoL and SF-36. CONCLUSION: After adjusting for disability and relapse
occurrence, sociodemographics (age, marital status, and occupational status) and
baseline QoL scores were also independent QoL predictors in MS patients. Special
attention should be given to subgroups to ensure optimal management.
CI - Copyright (c) 2014 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS