Article

Previous research has shown that low-frequency repetitive transcranial magnetic
stimulation over the primary motor area and supplementary motor area can reduce
L-dopa-induced dyskinesias in Parkinson's disease ; however, it involved only
patients with peak-dose or diphasic dyskinesia. We report a case of a patient
with severely painful off-period dystonia in the unilateral lower limb who
underwent 0.9-Hz subthreshold repetitive transcranial magnetic stimulation over
contralateral primary motor area and supplementary motor area. Repetitive
transcranial magnetic stimulation over the primary motor area significantly
reduced the painful dystonia and walking disturbances but repetitive transcranial
magnetic stimulation over the supplementary motor area did not. The cortical
silent period also prolonged after repetitive transcranial magnetic stimulation
over the primary motor area.
At 5 mos of approximately once a week repetitive
transcranial magnetic stimulation over the primary motor area, the Unified
Parkinson's Disease Rating Scale motor score also improved. This report shows
that repetitive transcranial magnetic stimulation over the inhibitory primary
motor area can be useful for rehabilitating patients with Parkinson's disease
with off-period dystonia and suggests that this treatment should be further
verified in such patients.

Langue : ANGLAIS