Article

The objective of this study was to examine relationships between
dimensions of physical frailty and severity of cognitive impairment in older
adults with amnestic mild cognitive impairment (aMCI). METHODS: The
prevalence of physical frailty dimensions including slow gait speed, low physical
activity, and low grip strength was examined among 201 sedentary older adults
with aMCI. Associations between dimensions of physical frailty and severity of
cognitive impairment, as measured with the Alzheimer's Disease Assessment
Scale-Cognitive Subscale (ADAS-Cog) and individual dimensions of cognitive
function were examined using multiple linear regression models. RESULTS: Greater
than 50% of participants met physical frailty criteria on dimensions of slow gait
speed, low physical activity and low grip strength. Slower gait speed was
associated with elevated severity of cognitive impairment. Both gait speed and
physical activity were associated with individual dimensions cognitive function.
CONCLUSIONS: Dimensions of physical frailty, particularly gait speed, were
associated with severity of cognitive impairment, after adjusting for age, sex
and age-related factors. Further studies are needed to investigate mechanisms and
early intervention strategies that assist older adults with aMCI to maintain
function and independence.
CI - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS ; FRANCAIS