Article

The collection of data on longer-term neurodevelopmental outcomes within
large neonatal randomized controlled trials by trained assessors can greatly
increase costs and present many operational difficulties. The aim of this study
was to develop a more practical alternative for identifying major cognitive delay
in infants at the age of 24 months, based on parental reports. METHOD: A sample
of 476 infants (206 female, 270 male) previously diagnosed with neonatal sepsis
(mean birthweight 1329g [SD 865g], mean gestational age at birth 28.7wks [SD
4.5wks]) from the International Neonatal Immunotherapy Study were assessed using
the Parent Report of Children's Abilities - Revised and the Bayley Scales of
Infant Development, 2nd edition. Logistic regression was used to model the
association between the risk of major cognitive delay (i.e. Bayley Scales of
Infant Development Mental Development Index <55) and the Parent Report of
Children's Abilities - Revised data. RESULTS: The receiver operating
characteristic curves for a number of predictive models were constructed - each
achieved an area under the curve of at least 90%. The sensitivity, specificity,
positive predictive value, and negative predictive value of a number of points on
the receiver operating characteristic curves are presented. INTERPRETATION: The
Parent Report of Children's Abilities - Revised is a practical tool for
identifying major cognitive delay in infants at 24 months.
CI - (c) The Authors. Developmental Medicine & Child Neurology (c) 2011 Mac Keith
Press.

Langue : ANGLAIS