Article

Inconsistencies regarding the risk of developing Alzheimer disease
after traumatic brain injury (TBI) remain in the literature. Indeed, why AD
develops in certain TBI patients while others are unaffected is still unclear.
OBJECTIVE: The aim of this study was to performed a systematic review to
investigate whether certain variables related to TBI, such as TBI severity, loss
of consciousness (LOC) and post-traumatic amnesia (PTA), are predictors of risk
of AD in adults. METHODS:
From 841 citations retrieved from MEDLINE via PubMed,
EMBASE, PSYINFO and Cochrane Library databases, 18 studies were eligible for the
review. RESULTS: The review revealed that about 55.5% of TBI patients may show
deteriorated condition, from acute post-TBI cognitive deficits to then meeting
diagnostic criteria for AD, but whether TBI is a risk factor for AD remains
elusive. CONCLUSIONS: Failure to establish such a link may be related to
methodological problems in the studies. To shed light on this dilemma, future
studies should use a prospective design, define the types and severities of TBI
and use standardized AD and TBI diagnostic criteria. Ultimately, an AD prediction
model, based on several variables, would be useful for clinicians detecting TBI
patients at risk of AD.
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Langue : ANGLAIS