Article

Freezing of gait (FoG) is associated with less automatic gait and more impaired
cognition, balance and postural transitions compared to people with PD who do not
have FoG. However, it is unknown whether dual-task cost during postural sway,
postural transitions (such as gait initiation and turning), and gait are more in
subjects with Parkinson's disease (PD) who have freezing of gait (FoG+) compared
to those who do not have FoG (FoG-). Here, we hypothesized that the effects of a
cognitive dual task on postural sway, postural transitions and gait would be
larger in FoG+ than FoG-. Thirty FoG- and 24 FoG+ performed an Instrumented Stand
and Walk test in OFF medication state, with and without a secondary cognitive
task (serial subtraction by 3s). Measures of postural sway, gait initiation,
turning, and walking were extracted using body-worn inertial sensors. FoG+ showed
significantly larger dual task cost than FoG- for several gait metrics, but not
during postural sway or postural transitions. During walking, FoG+ exhibited a
larger dual task cost than FoG- resulting in shorter stride length and slower
stride velocity. During standing, FoG+ showed a larger postural sway compared to
FoG- and during gait initiation, FoG+, but not FoG-, showed a longer first step
duration during the dual-task condition compared to single-task condition
(interaction effect, p=0.04). During turning, both groups showed a slower turn
peak speed in the dual-task condition compared to single task condition. These
findings partly support our hypothesis that dual task cost on walking is greater
in FoG+ than FoG-.
CI - Copyright (c) 2017. Published by Elsevier B.V.

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