Article

OBJECTIVE: To investigate the safety of combining a 6-Hz primed low-frequency
repetitive transcranial magnetic stimulation (rTMS) intervention in the
contralesional hemisphere with a modified constraint-induced movement therapy
(mCIMT) program in children with congenital hemiparesis.
DESIGN: Phase 1
randomized, double-blinded, placebo-controlled pretest/posttest trial. SETTING:
University academic facility and pediatric specialty hospital. PARTICIPANTS:
Subjects (N = 19; age range, 8-17 y) with congenital hemiparesis caused by
ischemic stroke or periventricular leukomalacia. No subject withdrew because of
adverse events. All subjects included completed the study. INTERVENTIONS:
Subjects were randomized to 1 of 2 groups: either real rTMS plus mCIMT (n = 10)
or sham rTMS plus mCIMT (n = 9). MAIN OUTCOME MEASURES: Adverse events, physician
assessment, ipsilateral hand function, stereognosis, cognitive function, subject
report of symptoms assessment, and subject questionnaire. RESULTS: No major
adverse events occurred. Minor adverse events were found in both groups. The most
common events were headaches (real: 50%, sham: 89%; P = .14) and cast irritation
(real: 30%, sham: 44%; P = .65). No differences between groups in secondary
cognitive and unaffected hand motor measures were found. CONCLUSIONS: Primed rTMS
can be used safely with mCIMT in congenital hemiparesis. We provide new
information on the use of rTMS in combination with mCIMT in children. These
findings could be useful in research and future clinical applications in
advancing function in congenital hemiparesis.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.
- Enfant

Langue : ANGLAIS