Article

OBJECTIVE: To compare the effects of trospium hydrochloride and electrical
stimulation on urodynamic parameters, bladder diary,
quality of life and
psychological symptoms in female patients with overactive bladder syndrome.
DESIGN: Prospective, randomized controlled trial. SETTING: Department of Physical
Medicine and Rehabilitation, University Hospital. SUBJECTS: Thirty-five patients
were divided into either trospium chloride (Group 1) or intravaginal electrical
stimulation therapy (Group 2). MAIN OUTCOME MEASURES:
All patients were assessed
at the beginning of the treatment, at weeks 6 (end of treatment), 10 and 18
according to urodynamic parameters, voiding diary parameters, severity of urgency
(visual analogue scale, VAS), the Incontinence Impact Questionnaire Short Form
(IIQ-7), and the Beck Depression Inventory. RESULTS: Statistically significant
improvements were observed in both groups according to some urodynamic
parameters, voiding diary parameters, VAS urgency severity, Incontinence Impact
Questionnaire Short Form and Beck Depression Inventory scores at the end of the
treatment (P<0.05). During the 18-week follow-up period, deteriorations were
observed in many parameters in both groups although improvements in the frequency
of urgency, the frequency of incontinence episodes, VAS urgency severity, and
Beck Depression Inventory score in Group 2 persisted (P<0.05). Significant
differences were not detected between groups at the end of the treatment or
during the posttreatment follow-up controls (P>0.05). CONCLUSION: No difference
was detected between trospium hydrochloride and intravaginal electrical
stimulation in the treatment of female overactive bladder syndrome.
Discontinuation of both treatments caused deterioration in most of the objective
and subjective symptoms of overactive bladder syndrome.

Langue : ANGLAIS