Article

Metabolic syndrome (MetS) is associated with increased risk for
cardiovascular disease, but there is heterogeneity in this risk. We evaluated
whether high-sensitivity troponin T (hs-cTnT), a marker associated with
cardiovascular disease, can stratify risk in MetS.
Methods : We evaluated
associations between MetS (and groups with similar number of MetS components) and
incident heart failure hospitalization, coronary heart disease, stroke and death
using hs-cTnT categories after adjusting for risk factors/markers between 1996
and 2011 in 8204 individuals in the Atherosclerosis Risk In Communities study.
Results The mean age of the population was 63 years (56% women, 19% Blacks).
hs-cTnT levels were higher with MetS and with increasing MetS components. In
individuals with MetS, higher hs-cTnT levels were associated with increased
hazard ratios for heart failure, coronary heart disease and death. Within each
number of MetS components, higher hs-cTnT was associated with progressively
higher heart failure, coronary heart disease and death hazards. The association
was particularly strong for heart failure. With increasing hs-cTnT categories,
the hazard ratios (95% confidence interval) for heart failure in individuals with
MetS increased gradually from 1.68 (1.31-2.16) to 3.76 (2.69-5.26) ( p-trend <
0.001) compared with those with MetS and hs-cTnT < 5 ng/l; and respective hazard
ratios with increasing hs-cTnT categories in those with all five MetS components
ranged from 2.22 (1.17-4.21) to 4.23 (1.89-9.50) ( p-trend 0.004) compared with
those with all five MetS components and hs-cTnT < 5 ng/l. However, mostly there
were no significant interactions of hs-cTnT with MetS or its components.
Conclusion : hs-cTnT is useful for identifying MetS patients with increased hazards
for coronary heart disease, death and particularly heart failure.

Langue : ANGLAIS