Article

OBJECTIVE: To determine whether impaired Timed Up and Go Test (TUG) subtask
performances are associated with specific cognitive domains among older people
with preserved cognition (PC), mild cognitive impairment (MCI), and mild
Alzheimer's disease (AD). DESIGN: TUG subtasks performances were assessed by the
Qualisys motion system. Cognition was assessed by Addenbrooke's Cognitive
Examination and the Frontal Assessment Battery (FAB). RESULTS: The highest
correlations with transition subtasks were with aspects of executive function,
i.e. the fluency domain in the PC group (n = 40), FAB scores in the MCI group (n
= 40), and the visuospatial domain in the AD group (n = 38). No significant
associations were found between the walking subtasks and cognition in any group.
Multivariate linear regression models identified the fluency domain as an
independent predictor of turn-to-walk and turn-to-sit measures in the PC group,
and the visuospatial domain as an independent predictor of turn-to-walk and
turn-to-sit measures in the AD group, adjusted for age and sex. CONCLUSIONS:
Poorer executive functioning was associated with impaired transition mobility in
all groups. The significant associations between visuospatial impairment and poor
transition mobility in the AD participants may provide insight into why this
group has an elevated fall risk.

Langue : ANGLAIS