Article

OBJECTIVE: To assess whether sensorimotor peripheral nerve function is associated
with muscle power in community-dwelling older men. DESIGN: Longitudinal cohort
study with 2.3+/-0.3 years of follow-up. SETTING: One clinical site.
PARTICIPANTS: Participants (n=372; mean age +/- SD, 77.2+/-5.1y; 99.5% white;
body mass index, 27.9+/-3.7kg/m(2); power, 1.88+/-0.6W/kg) at 1 site of the
Osteoporotic Fractures in Men Study (N=5994). INTERVENTIONS: Not applicable. MAIN
OUTCOME MEASURES: A nerve function ancillary study was performed 4.6+/-0.4 years
after baseline. Muscle power was measured using a power rig. Peroneal motor nerve
conduction amplitude, distal motor latency, and mean f-wave latency were
measured. Sensory nerve function was assessed using 10-g and 1.4-g monofilaments
and sural sensory nerve conduction amplitude and distal latency. Peripheral
neuropathy symptoms at the leg and feet were assessed by self-report. RESULTS:
After adjustments for age, height, and total body lean and fat mass, 1 SD lower
motor (beta=-.07, P<.05) and sensory amplitude (beta=-.09, P<.05) and 1.4-g
(beta=-.11, P<.05) and 10-g monofilament insensitivity (beta=-.17, P<.05) were
associated with lower muscle power/kg. Compared with the effect of age on muscle
power (beta per year, -.05; P<.001), this was equivalent to aging 1.4 years for
motor amplitude, 1.8 years for sensory amplitude, 2.2 years for 1.4-g
monofilament detection, and 3.4 years for 10-g detection. Baseline 1.4-g
monofilament detection predicted a greater decline in muscle power/kg. Short-term
change in nerve function was not associated with concurrent short-term change in
muscle power/kg. CONCLUSIONS: Worse sensory and motor nerve function were
associated with lower muscle power/kg and are likely important for impaired
muscle function in older men. Monofilament sensitivity was associated with a
greater decline in muscle power/kg, and screening may identify an early risk for
muscle function decline in late life, which has implications for disability.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS