RééDOC
75 Boulevard Lobau
F 54042 NANCY cedex

Documentaliste
03 83 52 67 64

HORAIRES
0

Article

--";3! O
     

-A +A

Fatigue is associated with global and regional thalamic morphometry in veterans with a history of mild traumatic brain injury

CLARK AL; SORG SF; HOLIDAY K
J HEAD TRAUMA REHABIL , 2018, vol. 33, n° 6, p. 382-392
Doc n°: 189136
Localisation : Centre de Réadaptation de Lay St Christophe

D.O.I. : http://dx.doi.org/10.1097/HTR.0000000000000377
Descripteurs : AF3 - TRAUMATISME CRANIEN



Objective: Fatigue is a complex, multidimensional phenomenon that commonly occurs following traumatic brain injury (TBI). The thalamus²a structure vulnerable to both primary and secondary injuries in TBI²is thought to play a pivotal role in the manifestation of fatigue. We explored how neuroimaging markers of local and global thalamic morphometry relate to the subjective experience of fatigue post-TBI.

Methods: Sixty-three Veterans with a history of mild TBI underwent structural magnetic resonance imaging and completed questionnaires related to fatigue and psychiatric symptoms. FMRIB's Software (FSL) was utilized to obtain whole brain and thalamic volume estimates, as well as to perform regional thalamic morphometry analyses.

Results: Independent of age, sex, intracranial volume, posttraumatic stress disorder, and depressive symptoms, greater levels of self-reported fatigue were significantly associated with decreased right (P = .026) and left (P = .046) thalamic volumes. Regional morphometry analyses revealed that fatigue was significantly associated with reductions in the anterior and dorsomedial aspects of the right thalamic body (P < .05). Similar trends were observed for the left thalamic body (P < .10).

Conclusions: Both global and regional thalamic morphometric changes are associated with the subjective experience of fatigue in Veterans with a history of mild TBI. These findings support a theory in which disruption of thalamocorticostriatal circuitry may result in the manifestation of fatigue in individuals with a history of neurotrauma.
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

Langue : ANGLAIS

Contenu dans

Mes paniers

4

Gerer mes paniers

0
0