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Total hip arthroplasty in severe congenital factor VII deficiency - Successful use of recombinant activated factor VII for hemostasis
NIIKURA T; NISHIKAWA T; SAEGUSA Y; FUJISHIRO T; YOSHIYA S; KUROSAKA M
J ARTHROPLASTY , 2005, vol. 20, n° 3, p. 396-400 Doc n°: 119763 Localisation : Documentation IRR Descripteurs : DE361 - TRAITEMENT CHIRURGICAL / HANCHE Congenital factor VII (FVII) deficiency is a rare hemorrhagic disorder, and, in affected patients, Surgery is likely to cause excessive bleeding. In this article, we report the first case of total hip arthroplasty in a patient with severe congenital FVII deficiency in which recombinant activated factor VII (rFVIIa, NovoSeven) was successfully used to manage bleeds. The patient was a 68-year-old woman with severe congenital FVII deficiency, who suffered front a hemorrhagic arthrosis of her left hip joint. We administered rFVIIa as intermittent bolus infusions both perioperatively and postoperatively; dosing was based on the results of a preoperative rFVIIa challenge test. During surgery and the 3-day postoperative treatment period, we observed normal hemostasis with no excessive bleeding or complications. Langue : ANGLAIS Tiré à part : OUI |
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