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Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis
MORELAND LW
ARTHRITIS RES THER , 2003, vol. 5, n° 2, p. 54-67 Doc n°: 109082 Localisation : Documentation IRR Descripteurs : DA6 - TRAITEMENTS - APPAREIL LOCOMOTEUR Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid) (HA) and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in vivo, in vitro, and clinical studies demonstrate various physiological effects of exogenous HA. HA can reduce nerve impulses and nerve sensitivity associated with the pain of OA. In experimental OA, this glycosaminoglycan has protective effects on cartilage, which may be mediated by its molecular and cellular effects observed in vitro. Exogenous HA enhances chondrocyte HA and proteoglycan synthesis, reduces the production and activity of proinflammatory mediators and matrix metalloproteinases, and alters the behavior of immune cells. Many of the physiological effects of exogenous HA may be a function of its molecular weight. Several physiological effects probably contribute to the mechanisms by which HA and hylans exert their clinical effects in knee OA. Langue : ANGLAIS Tiré à part : OUI Identifiant basis : 2003227180 |
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