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Gabapentin-induced hypersensitivity syndrome
RAGUCCI MV; COHEN JM
CLIN NEUROPHARMACOL , 2001, vol. 24, n° 2, p. 103-105 Doc n°: 100045 Localisation : Documentation IRR Descripteurs : AA - GENERALITES - SYSTEME NEUROMUSCULAIRE Hypersensitivity syndrome is a rare but potentially fatal reaction to some pharmacologic agents, including some antiepileptic drugs. Typically, the syndrome presents with fever, rash, tender lymphadenopathy, hepatitis, and eosinophilia. We report a novel case of clinical hypersensitivity syndrome secondary to gabapentin. A patient developed altered mental status, fever, diffuse macular rash, and an enlarged spleen. This constellation of symptoms and signs began 9 days after gabapentin therapy was begun. Quick resolution was noted after gabapentin was discontinued. To our knowledge, there are no reports of hypersensitivity syndrome to gabapentin. Langue : ANGLAIS Tiré à part : OUI Identifiant basis : 2001215985 |
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