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Continual supplementation with n-3 fatty acids does not modify plasma lipid profile in spinal cord injury patients
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JAVIERRE C; VIDAL J; SEGURA R; MEDINA J; GARRIDO E
SPINAL CORD , 2005, vol. 43, n° 9, p. 527-530 Doc n°: 121578 Localisation : Centre de Réadaptation de Lay St Christophe , en ligne Descripteurs : AE21 - ORIGINE TRAUMATIQUE Url : http://www.nature.com/sc/archive/index.html A prospective study during a diet modification. Objective: To observe the evolution of the plasma lipid pro. Le in a group of spinal cord injury (SCI) patients given a supplement of a mixture of docosahexanoic acid (DHA) and eicosapentaenoic acid (EPA). Setting: Department of Physiological Sciences II, Medical School of the University of Barcelona and Guttmann Institut of Badalona, Barcelona, Spain. Methods: A total of 19 adult males with SCI, 17 with paraplegia and two with tetraplegia, were given a daily supplement of 1.5 g of DHA and 0.75 g of EPA for 6 months. Determination of plasma values of DHA, EPA, total cholesterol, HDL-c, LDL-c, VLDL-c, triglycerides, and glucose was performed before supplementation and at 3 and 6 months of supplementation. Results: A statistically significant increase in the plasma concentration of EPA ( F = 30.556, P<0.05) and DHA ( F = 106.6, P<0.05) was observed after 3 and 6 months of supplementation. However, there were no observable differences in the plasma concentration of total-cholesterol, HDL-c, LDL-c, VLDL-c, and triglycerides during the study. Conclusion: DHA - EPA supplementation for 6 months does not modify the glycemic and lipid plasmatic levels in SCI patients. Despite its absence of effect on the serum lipid profile, n-3 fatty acids may induce beneficial cardiovascular effects in this population. Langue : ANGLAIS |
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